Pterostilbene (Dimethylresveratrol)

Overview of Pterostilbene (Dimethylresveratrol)

Pterostilbene (Dimethylresveratrol) is a naturally occurring polyphenolic stilbene compound found at low concentrations in certain plant species, including blueberries (Vaccinium spp.), grapes (Vitis spp.), and select tree barks. Structurally, it is a dimethylated analog of resveratrol, with two methoxy groups replacing hydroxyl groups, which has led researchers to study its in vitro and preclinical properties related to intracellular signaling, antioxidant capacity, and metabolic regulation.

It is important to note that Purerawz only offers Pterostilbene as a research chemical intended solely for laboratory use.

Chemical and Molecular Properties 

Pterostilbene (Dimethylresveratrol)
PubChem CID	5281727
Molecular Formula	C16H16O3
Synonyms	trans-pterostilbene 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol pterostilbene, (E)-
Molecular Weight	256.30 g/mol
IUPAC	4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
Chemical Structure Depiction
CAS	537-42-8
Storage Temperature	2–8°C (refrigerated, protected from light)
Solubility	Insoluble in water; soluble in DMSO

Mechanism of Action

In experimental in vitro and preclinical models, pterostilbene has been associated with several intracellular responses:

Activation of SIRT1 in Experimental Models

Pterostilbene has been reported to modulate sirtuin–1 (SIRT1) activity in laboratory studies. SIRT1 is a class III histone deacetylase linked to the regulation of cellular stress response and energy metabolism. In research contexts, compounds that engage SIRT1 are used to explore gene expression profiles influenced by deacetylation pathways.

Antioxidant Activity

As a polyphenolic stilbene, pterostilbene exhibits ROS–scavenging activity in cellular assays, which is used to investigate mechanisms of redox homeostasis and oxidative damage in cultured cells. These antioxidant effects are examined in biochemical studies to assess interactions with reactive oxygen species and cellular defense mechanisms.

Modulation of AMPK Pathway

In laboratory models, pterostilbene has been shown to interact with the AMP–activated protein kinase (AMPK) signaling network. AMPK functions as a cellular energy sensor, and its activation in research settings is associated with studies of metabolic regulation and bioenergetic homeostasis.

Anti–Inflammatory Actions in Research Settings

Pterostilbene has been observed to influence inflammatory signaling pathways in in vitro systems, including modulation of NF‑κB activation and downstream cytokine expression. These responses are investigated to improve understanding of inflammatory mediator regulation.

Research Applications of Pterostilbene

Pterostilbene is employed across various experimental models to investigate cellular signaling and biochemical processes:

• Cellular Oxidative Stress Studies
• Inflammatory Pathway Analysis
• Energy Metabolism and AMPK Signaling Research
• Sirtuin Regulation Studies

Why Choose PureRawz for Pterostilbene (Dimethylresveratrol)?

Buy Pterostilbene (Dimethylresveratrol) for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

Pterostilbene (Dimethylresveratrol)  is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

PubChem Compound Summary for Pterostilbene (CID 5281727).PubChem. National Center for Biotechnology Information, U.S. National Library of Medicine.https://pubchem.ncbi.nlm.nih.gov/compound/5281727

Liu D., Ma Z., Xu L., et al. PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades. Aging (Albany NY). 11(22):10061–10073. 2019. https://pubmed.ncbi.nlm.nih.gov/31733141/

Xu C., Song Y., Wang Z., et al. Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO‑1 pathways. Immunity, Inflammation and Disease. 9(4):1406–1417. 2021. https://pubmed.ncbi.nlm.nih.gov/34342160/

Cheng Y., Di S., Fan C., et al. SIRT1 activation by pterostilbene attenuates skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury.Apoptosis. 21(8):905–916. 2016. https://pubmed.ncbi.nlm.nih.gov/27270300/

Liu P., Zhang Y., Gao J., et al. Pterostilbene attenuates inflammatory and fibrotic processes: involvement of NF‑κB and related pathways. Frontiers in Pharmacology. 2024.
https://www.frontiersin.org/articles/10.3389/fphar.2023.1323377/full 

McCormack D.G. & McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxidative Medicine and Cellular Longevity. 2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/