FLModafinil (CRL-40,940)

Overview of FLModafinil

FLModafinil, also referenced in scientific literature as CRL-40,940 or bisfluoromodafinil, is an investigational compound structurally derived from modafinil, a diphenylmethyl sulfinylacetamide derivative. The compound belongs to a class of synthetic molecules studied in experimental neuropharmacology research for their interactions with neurotransmitter systems involved in wakefulness regulation and neural signaling.

Structurally, FLModafinil differs from modafinil through the substitution of two para-fluorine atoms on the phenyl rings, producing a bis-fluoro analog. This modification has been investigated in structure-activity relationship (SAR) studies examining how chemical substitutions influence pharmacological properties, receptor interactions, and transporter affinity in laboratory research models.

Within preclinical and in vitro investigations, FLModafinil has been evaluated for its potential interactions with neurotransmitter transporters and intracellular signaling systems associated with dopaminergic pathways. Because of its structural similarity to modafinil, research interest has focused on understanding how fluorinated derivatives influence neurotransmitter transporter modulation and cellular signaling processes.

Chemical and Molecular Properties

Working Mechanism

Dopamine Transporter Interaction in Experimental Models

Experimental pharmacology research has investigated FLModafinil for its potential interaction with the dopamine transporter (DAT), a membrane protein responsible for regulating dopamine reuptake within synaptic spaces.

In in vitro transporter assays, compounds structurally related to modafinil have been examined for their ability to interact with DAT, influencing the reuptake process that regulates extracellular dopamine concentrations. Research models suggest that inhibition or modulation of this transporter can alter dopaminergic signaling dynamics within neuronal systems.

Neurotransmitter Signaling Pathways

Experimental studies examining modafinil analogues, including FLModafinil, have also explored interactions with broader neurotransmitter systems involved in arousal regulation and neurochemical signaling.

Laboratory investigations suggest that these compounds may influence signaling pathways associated with:

• dopaminergic neurotransmission
• glutamatergic signaling pathways
• orexin and histamine regulatory networks associated with wakefulness signaling

Structure-Activity Relationship (SAR) Research

The fluorinated phenyl substitution present in FLModafinil has been examined in structure-activity relationship studies exploring how chemical modifications influence transporter interactions and molecular signaling properties.

Research comparing modafinil and fluorinated derivatives investigates how structural differences affect:

• transporter-binding affinity
• lipophilicity and molecular stability
• signaling pathway activation in neuronal research models

Research Applications of FLModafinil in Laboratory Settings

Dopamine Transporter Research

Experimental studies may investigate how FLModafinil interacts with dopamine transporters using in vitro uptake assays and transporter-binding experiments.

Neurochemical Signaling Studies

Research models may explore the compound’s influence on dopaminergic and glutamatergic signaling networks through biochemical pathway analysis and neurotransmitter measurement techniques.

Structure-Activity Relationship Investigations

FLModafinil may be included in comparative studies examining structural modifications of modafinil analogues and their influence on transporter affinity and molecular signaling interactions.

Experimental Neuropharmacology Models

Laboratory experiments may use the compound in research exploring neurotransmitter regulation mechanisms, intracellular signaling pathways, and molecular interactions within neuronal systems.

Note: FLModafinil is not approved by the FDA for human consumption. It is available for research purposes only.

Why Choose Purerawz for FLModafinil?

Buy FLModafinil for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

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Reference Links

PubChem. (2026). 2-((Bis(4-fluorophenyl)methyl)sulfinyl)acetamide. Nih.gov; PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/2-bis4-fluorophenylmethylsulfinylacetamide

Napoletano, F., Schifano, F., Corkery, J. M., Guirguis, A., Arillotta, D., Zangani, C., & Vento, A. (2020). The psychonauts world of cognitive enhancers. Frontiers in Psychiatry, 11, 546796. https://doi.org/10.3389/fpsyt.2020.546796