Ibutamoren (MK-677)

Overview of MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren, is a compound being studied for its ability to mimic ghrelin, a hormone that triggers growth hormone (GH) release. Although MK-677 is not FDA-approved for medical use, preclinical and clinical studies have demonstrated that it increases circulating GH and IGF-1 levels. Current research continues to investigate its pharmacology and potential therapeutic applications.

Chemical and Molecular Properties 

MK-677
PubChem CID	6450830
Molecular Formula	C27H36N4O5S
Synonyms	MK-677 Ibutamoren Ibutamoren Mesylate Butamoren CAS 159634-47-6
Molecular Weight	528.7 g/mol
IUPAC	2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
Chemical Structure Depiction
CAS	159634-47-6
Hazards	Comprehensive hazard classification under GHS has not been fully established. Handle using standard laboratory safety precautions.
Classification	Research Use Only (RUO)
Storage Temperature	Store at 2–8°C for short-term storage or according to the manufacturer’s Certificate of Analysis. For long-term storage, follow supplier recommendations and protect from moisture and light.
Solubility	DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml

How MK-677 Works

MK-677 is a small molecule that functions as an agonist of the ghrelin receptor (GHSR-1a). Activation of GHSR-1a in the hypothalamus and pituitary modulates neuroendocrine signaling that stimulates pulsatile secretion of growth hormone from anterior pituitary somatotroph cells. The increase in GH levels subsequently elevates insulin-like growth factor 1 (IGF-1), a downstream mediator of GH signaling that regulates protein synthesis, cellular proliferation, differentiation, and tissue remodeling.

Research Applications of MK-677

In research models, this pathway is studied for its effects on:

• GH/IGF-1 signaling is studied for its role in regulating protein synthesis, protein turnover, and nitrogen balance in experimental models.
• Tissue growth: GH and IGF-1 signaling is investigated for its role in regulating cellular proliferation and differentiation in skeletal muscle and other tissues.
• Structural tissue density: GH and IGF-1 signaling is investigated for its influence on osteoblast activity, bone remodeling, and extracellular matrix maintenance in experimental models.
• GH signaling is associated with lipid mobilization and metabolic regulation, while IGF-1 participates in downstream anabolic signaling.

MK-677 acts as a non-peptide ghrelin mimetic, meaning it can trigger the ghrelin receptor without being a peptide hormone itself, making it useful for studying GH/IGF-1 axis regulation in various model systems.

What does MK-677 typically look like?

MK-677 is generally supplied as a white to off-white crystalline powder. Slight variations in appearance may occur depending on manufacturing and storage conditions.

How is MK-677 characterized?

Identity is commonly confirmed using LC-MS, while purity is typically assessed using RP-HPLC. Researchers commonly review Certificates of Analysis (COAs) before experimental use.

How does MK-677 differ from growth hormone?

MK-677 does not contain growth hormone. Instead, it functions as a ghrelin receptor agonist that stimulates endogenous growth hormone secretion in experimental models.

Why Choose PureRawz for MK-677?

Buy MK-677 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

MK-677 is an investigational compound currently undergoing clinical evaluation and has not been established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

Reference Links

• Smith RG, Van der Ploeg LHT, Howard AD, et al. Peptidomimetic regulation of growth hormone secretion. Endocrine Reviews. 1997;18(5):621–645. https://doi.org/10.1210/edrv.18.5.0312
• Chapman IM, Bach MA, Van Cauter E, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of the GH secretagogue MK-677 in healthy elderly subjects. Journal of Clinical Endocrinology & Metabolism. 1996;81(12):4249–4257. https://doi.org/10.1210/jcem.81.12.8954023
• Murphy MG, Bach MA, et al. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. Journal of Clinical Endocrinology & Metabolism. 1998;83(2):320–325. https://doi.org/10.1210/jcem.83.2.4557
• Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: A randomized trial. Annals of Internal Medicine. 2008;149(9):601–611. https://doi.org/10.7326/0003-4819-149-9-200811040-00003
• Costantino L, Barlocco D. Ghrelin receptor modulators and their therapeutic potential. Future Medicinal Chemistry. 2009;1(1):157–177. https://doi.org/10.4155/fmc.09.9
•  PubChem. Ibutamoren (MK-677). National Center for Biotechnology Information. https://pubchem.ncbi.nlm.nih.gov/compound/6450830