Lipo-C LC120 Research Blend

Overview

Lipo-C LC120 is a four-component lipotropic amino acid and vitamin research blend formulated as an injectable solution at 120mg/mL total concentration. It contains L-methionine (15mg/mL), choline chloride (50mg/mL), L-carnitine (50mg/mL), and dexpanthenol (provitamin B5, 5mg/mL). None of the four components is a peptide — no component contains two or more amino acids joined by peptide bonds — and none interacts with androgen receptors. The blend is correctly classified as a lipotropic amino acid/vitamin complex for laboratory research investigation of fatty acid oxidation, one-carbon metabolism, and hepatic lipid processing pathways. It is not FDA-approved for any use, is not a dietary supplement, and is supplied strictly for laboratory research.

Chemical Properties

Mechanisms Investigated in Preclinical Research

L-Carnitine → CPT-1/OCTN2 Long-Chain Fatty Acid Mitochondrial Transport: L-Carnitine is observed in preclinical models to function as an obligate co-substrate for carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting enzyme at the outer mitochondrial membrane that transfers long-chain acyl groups from acyl-CoA to carnitine to form acylcarnitine. This acylcarnitine then crosses the inner mitochondrial membrane via the carnitine-acylcarnitine translocase (CACT) for subsequent β-oxidation by CPT-2. Published data (Longo et al. 2016, Biochim Biophys Acta, PMID 26828774) indicate that OCTN2 (SLC22A5), the high-affinity Na⁺-dependent carnitine transporter, mediates cellular carnitine uptake and renal reabsorption, with defects in OCTN2 producing primary carnitine deficiency in animal models.

Choline and Methionine → Hepatic Methyl Carbon Metabolism and VLDL Export: Choline and methionine have been investigated in bovine neonatal hepatocyte models for their differential effects on methyl carbon metabolism. Published data (Chandler & White 2017, PLoS ONE, PMID 28192459) indicate that increasing choline chloride concentration increased expression of MTR and MTHFR (one-carbon pathway genes), increased VLDL export, and decreased ROS accumulation in hepatocyte media — suggesting choline may protect against hepatic lipid accumulation via VLDL secretion enhancement. Methionine’s role as the universal methyl donor (via S-adenosylmethionine, SAM) is observed to regulate phosphatidylcholine synthesis through the PEMT pathway.

Dexpanthenol → Coenzyme A Biosynthesis Pathway: Dexpanthenol (D-pantothenol) is the alcohol analogue of pantothenic acid (Vitamin B5), investigated as a provitamin that is oxidized in vivo to pantothenic acid. Pantothenic acid is the obligate precursor for coenzyme A (CoA) biosynthesis via a 5-step pathway initiated by pantothenate kinase (PanK). In preclinical metabolic research models, CoA availability is rate-limited by PanK activity and pantothenate concentration, making dexpanthenol relevant to studies of CoA-dependent fatty acid metabolism and acetyl-CoA production.

Research Applications

•       L-Carnitine/CPT-1 pathway investigation in cell-free mitochondrial fatty acid oxidation assay systems
•       Hepatic VLDL export and choline/methionine methyl group flux studies in primary hepatocyte models
•       CoA biosynthesis rate-limiting step research using pantothenate/dexpanthenol dose-response in metabolic cell models
•       Lipotropic blend comparative pharmacology: isolation of individual component contributions to fatty acid metabolism endpoints in controlled in vitro systems
•       Reference reagent for injectable lipotropic formulation stability and component degradation kinetics research

Risk & Handling

Handling Precautions

•       Handling must be performed by trained laboratory personnel only in a controlled laboratory environment
•       PPE required: nitrile gloves, laboratory coat, and eye protection minimum
•       Do not inhale solution aerosol during pipetting or transfer operations

Exposure Risks

•       Risk Tier: MODERATE — all four components are essential nutrients or cofactors but are formulated at supratherapeutic research concentrations in injectable form. No acute toxicity was documented at research concentrations in published cell model literature. No human safety data has been established for this specific co-formulated research blend at injectable concentration levels.
•       Choline at supraphysiological concentrations has been documented to alter VLDL export and ROS metabolism in hepatocyte models; researchers designing hepatic endpoint studies should account for this as a variable

Storage

•       Refrigerate at 2–8°C; protect from light throughout storage. Do not freeze.
•       Stable for ≥24 months under recommended refrigerated conditions

Quality Assurance

•       Identity confirmation by nuclear magnetic resonance (NMR) spectroscopy and/or mass spectrometry (MS)
•       Purity ≥98% by high-performance liquid chromatography (HPLC)
•       Moisture content tested per USP standards where applicable
•       Microbial testing for aerobic bacteria, yeast, and mould per USP <61> and <62>
•       Heavy metals analysis (Pb, Cd, As, Hg) per USP <232>/<233> standards
•       Full batch traceability with unique lot number documentation
•       Certificate of Analysis (COA) available upon request for every batch
•       Safety Data Sheet (SDS) available for all products

Why PureRawz

PureRawz supplies Lipo-C LC120 as a rigorously tested research-grade compound. Each batch undergoes independent third-party identity confirmation by NMR and HPLC with purity ≥98% verified. Where supplier specifications for complex blends or novel fusion compounds vary across vendors, PureRawz applies batch-specific molecular identity confirmation to verify component presence and ratio accuracy. A Certificate of Analysis (COA) documenting identity, purity, and lot traceability is available for every batch. A Safety Data Sheet (SDS) is provided for all products. Researchers requiring absolute certainty on batch composition for publication-quality study design should request COA documentation before initiating protocols.

References

•       Longo N, Frigeni M, Pasquali M. Carnitine transport and fatty acid oxidation. Biochimica et Biophysica Acta. 2016;1863(10):2422–2435. https://pubmed.ncbi.nlm.nih.gov/26828774/ [PMID 26828774]
•       Chandler TL, White HM. Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes. PLoS ONE. 2017;12(2):e0171080. https://pubmed.ncbi.nlm.nih.gov/28192459/ [PMID 28192459]

Disclaimer: Preclinical and published scientific research indicates potential mechanisms of action for this compound in laboratory and animal models. Any references to published studies are for informational purposes only and do not constitute a claim that this product produces the same effects in humans. The safety and efficacy of this compound in humans have not been established.

ATTENTION: All products sold by PureRawz are intended for laboratory and research purposes only and are not approved for human consumption, veterinary use, or any other use. Products are not evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Customers assume full responsibility for the lawful use of these products in accordance with all applicable federal, state, and local regulations.