3 5 Diiodo L-Thyronine (T2)

3 5 Diiodo L-Thyronine T2 – Product Details

Thyroid hormones (THs) from the thyroid gland are essential endocrine elements that play vital biological roles, such as governing energy metabolism and body weight.

A known thyroid hormone (TH) derivative 3, 5-diiodo-L-thyronine (or 3,5-T2), is found in biological fluids and significantly affects energy metabolism. 3,5-T2 increases the metabolic rate, cold tolerance, and lipid metabolism among animal models. [R]

The thyroid controls metabolism, and thyroid hormone derivatives are expected to mimic thyroid hormone regulation, 3,5 T-2 included. The hormone under consideration is also believed to affect mitochondrial fatty acid oxidation. [R]

Although 3 5 diiodo l-thyronine could promote thyroid hormone metabolism and its alleged medical beneficial effects, this chemical is still considered a research compound. 3 5 diiodo l-thyronine is inadvisable for human consumption.

Pure Rawz sells this product for research purposes only.

T2 3,5-diiodo-L-thyronine
CAS Number	1041-01-6
Molar Mass	525,077 g/mol
Chemical Formula	C15H13I2NO4
IUPAC Name	(2S)-2-amino-3-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]propanoic acid

What is 3 5 Diiodo L-Thyronine T2?

3 5 diiodo l-thyronine T2 is an endogenous derivative of thyroid-stimulating hormone that has been proposed to regulate energy expenditure, resting metabolic rate, and hepatic oxygen consumption via a mechanism involving mitochondrial function activation.

It significantly reduces body fat accumulation in overweight rats fed a high-fat diet (HFD), a risk factor for developing an inflammatory state and related metabolic diseases.

The chemical, as a thyroid-stimulating hormone, also stimulates thyroid-sensitive tissues. A study among Wistar rats from 3 to 6 months of age seems to prove this characteristic of 3,5 diiodo l-thyronine. [R]

Possible Applications of 3 5 Diiodo L-Thyronine T2

3 5 Diiodo L-Thyronine T2 may help in body weight loss

Akin to other thyroid hormones, T2 is allegedly capable of affecting weight loss.

The thyroid hormone derivative can increase energy expenditure and prevent high-fat diet-induced obesity and metabolic dysfunction. Most 3 5 diiodo l-thyronine research has focused on the liver and skeletal muscle. [R]

Given the importance of brown adipose tissue (BAT) in energy and metabolic homeostasis, researchers investigated whether 3 5 diiodo l-thyronine could activate BAT thermogenesis. [R]

Indeed, the discovery of functional BAT in adult humans and its essential role in energy metabolism and potential control of triglyceride clearance and glucose disposal suggests that T2 may be able to prevent metabolic dysfunction and related diseases in humans. [R]

Furthermore, 3 5 diiodo l-thyronine may aid in weight loss during caloric restriction (i.e., dieting). [R]

In another study on two healthy individuals, an 8-day 3,5-T2 dose-escalation protocol increased resting metabolic rate. It decreases body weight with no changes or adverse effects on serum thyroid stimulating hormone (TSH), thyroid hormone (TH), thyroid and cardiac function, blood pressure, or serum metabolic parameters such as glycemia, total cholesterol, and triglycerides. [R] [R]

Even though 3,5-T2 could help with weight loss management, this experimental compound still requires large-scale clinical trials before becoming a prescribed fat-burning compound.

3 5 Diiodo L-Thyronine T2 ameliorates diabetic neuropathy

Thyroid function has been examined through the kinetics of glucose-induced insulin secretion from the isolated perfused rat pancreas. [R]

T2 was found to prevent a significant decrease in SIRT1 protein expression and activity, as well as increases in blood glucose, urine albumin excretion, matrix expansion, transforming growth factor-1 expression, fibronectin, and type IV collagen deposition in diabetic kidneys. [R]

T2 had similar effects in cultured rat mesangial cells (RMC) exposed to high glucose, which could be reversed by sirtinol, a known SIRT1 inhibitor. [R]

These findings suggested that T2 was a protective agent against renal damage in diabetic neuropathy, with an action that involved SIRT1 regulation. [R]

Despite the alleged effects observed, 3,5 diiodo l thyronine is not a recommended form of cure for diabetic neuropathy. More safe and approved human trials are required here.

3 5 Diiodo L-Thyronine T2 may prevent diet-induced insulin resistance

T2, by activating SIRT1, sets off a chain of events that improves the serum lipid profile, prevents fat accumulation, and averts diet-induced insulin resistance. [R]

Nevertheless, the outcome of the stated research cannot be treated as conclusive. More tests are needed.

3 5 Diiodo L-Thyronine T2 may lessen the oxidative capacity

Long-term T2 treatment promotes visceral adipose lipolysis via HSL activation and effects on adipocyte morphology (observable after two weeks and persistent after 4 weeks), tissue vascularization, and proteins involved in lipid storage and oxidative stress. [R]

The current study’s findings indicate that T2 is effective in combating inflammation and oxidative stress caused by a long-term high-fat diet in rats. [R]

How Does 3 5 Diiodo L-Thyronine T2 Work?

3,5-Diiodo-L-thyronine (3,5-T2) is a metabolite of thyroid hormone. In cell-free assays, it binds to thyroid hormone receptors 1 (TR1), 1 (TR1), and 2 (EC50s = 0.8, 0.79, and 0.1 M, respectively).

Two 3,5-T2 (1 pM) increases oxygen consumption in perfused livers isolated from rats with sodium iodide-induced hypothyroidism.

When administered to animal models at a dose of 2.5 g/g per day, it reduces subcutaneous and epididymal fat mass and serum leptin and cholesterol levels without affecting body weight in high-fat diet-induced obese mice.

Safety and Side Effects

T2 has been shown in obese mice to produce signs of thyrotoxicosis while decreasing body weight and blood glucose levels.